FAPI/PSMA 探针
FAPI/PSMA 探针
FAPI/PSMA 探针。
FAPI
FAPI是一种放射性示踪剂，全称为成纤维细胞活化蛋白抑制剂。为小分子酶活性抑制剂，FAP抑制剂（FAPI）对CAF膜表面的FAP具有高度亲和力及特异性，可用于PET显像，灵敏度高，有利于FAP表达阳性疾病的无创性早期诊断、分期、鉴别诊断和预后评估。FAPI通过与FAP结合，可在PET-CT扫描中可视化肿瘤的位置和大小，从而帮助确定肿瘤的类型和位置，并指导肿瘤治疗的选择。FAPI被认为是一种具有潜在应用前景的新型肿瘤显像剂。
PSMA
前列腺特异性膜抗原（prostate-specificmembraneantigen，PSMA）是存在于前列腺细胞膜的一种多功能的Ⅱ型跨膜蛋白，由750个氨基酸残基组成。PSMA具有较高的前列腺组织特异性，在区分前列腺癌和其他类型恶性肿瘤的敏感度和特异性分别是65.9%和94.5%，因此PSMA仍然是前列腺癌细胞上一个相当敏感的、高度特异性的抗原物质。PSMA在前列腺组织良、恶性鉴别中优于PSA，且临床分期越晚，其表达越强，与肿瘤恶性程度成正相关。因此PSMA是较PSA更具特异性的前列腺癌瘤标志物，可作为前列腺癌预后评估的重要指标。
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